The drug Tranexamic acid tablet 250 mg "YD" is used in medicine and cosmetology.
In medicine, as an aniplasmin, in cosmetology it is used against pigmentation, as a vasoconstricting, anticooking, reparative medical treatment
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Nichijin "Tranexamic acid tablet 250 mg "YD" x 100tab
The Tranexamic acid tablet 250 mg "YD" is used in medicine and cosmetology.
Use in medicine.
Pharmacotherapeutic group Hemostatic preparations.
Inhibitors of fibrinolysis.
Absorption of tranexamic acid from the gastrointestinal tract is incomplete. The peak concentration of tranexamic acid in the blood plasma occurs 3 hours after the administration of a dose of 1 g. Bioaccumulation of the drug is approximately 34%; the presence of food does not affect the absorption. At plasma concentrations of 5 to 10 mg / L, Tranexamic acid binds to only 3% of blood proteins and is evidently completely with plasminogen. The metabolism of tranexamic acid has not been sufficiently studied. After taking drug at a dose of 2 g, approximately 2% appears in the urine in the form of acetylated and dicarboxylic acid metabolites for 25 hours. It is excreted mainly with urine - 95% Pharmacodynamics Antifibrinolytic agent. Tramine specifically inhibits the action of the plasmin activator and plasminogen, as a result degradation of fibrin by plasmin is inhibited.
Indications for use
With bleeding due to increased total and local fibrinolysis:
hemorrhagic complications of fibrinolytic therapy
leukemia - bleeding during surgery and in the postoperative period, uterine at delivery, pulmonary, nasal, gastrointestinal
menopausal and metrorrhagia
macrogemuria due to bleeding from the lower parts of the urinary system
Methods of administration and dose Inside, regardless of food intake - 250-500 mg 3-4 times a day. With profuse uterine bleeding - 1 g 1-2 times a day for 3-4 days. With repeated nasal bleeding - 1 g 2 times a day for 7 days. After surgery on the cervix - 1 g 2 times a day for 12-14 days. Patients with coagulopathies, before extraction of the tooth - 25 mg / kg 3-4 times a day, starting 1 day before the forthcoming operation and continuing for 6-8 days after.
With hereditary angioneurotic edema - inside, 1 g 1-2 times a day. In the event of a violation of the excretory function of the kidneys, correction of the dosing regimen is necessary: at a creatinine concentration in the blood of 120-250 μmol / L - 15 mg / kg 2 times a day; 250-500 μmol / l - in the same single dose once a day; more than 500 μmol / l - 7.5 mg / kg once a day
Use in cosmetology.
Tranexamic acid-fight against pigmentation. Melanin is a pigment that protects the skin from the harmful effects of sunlight. Melanin is used by the skin to dissipate accumulated heat and, thus, to reduce damage in the skin and its DNA. But in consequence of a certain lifestyle, nutrition, antibiotic use, the body becomes contaminated, hormonal disruptions occur, and we can observe in humans HYPERPIGMENTATION is an uneven accumulation of melanin in the skin, in which some of its areas become noticeably darker in color than the surrounding areas. Also we start to struggle actively with these pigmentary stains. Most often, such spots can be found on the aging skin, in the elderly. On these spots you can even identify with which body the problems are. Tranexamic acid in the skin acts like this: it blocks the signal about the need to produce melanin. That is, it is not an acid that, like salicylic or AHA, corrodes, roughly speaking, the skin, causing exfoliation.
Tranexamic acid is very widely used in Asian countries for skin bleaching, while in Europe, particularly in Germany, it is used as an antifibrinolytic drug.
Tranexamic acid inhibits the dissolution process of blood clots and thus prevents bleeding. And it is useful not only in medicine! The fact is that due to the normalizing effect on the activity of the fibrin protein, this ingredient reduces inflammation, the reddish color of the blood vessels and, consequently, improves the appearance of the skin as a whole. The beginning of the use of tranexamic acid in cosmetics is associated with occasional clinical observation. A patient who received tranexamic acid for subarachnoid hemorrhage noted a significant decrease in melasma. Further studies of tranexamic acid have shown that it is effective in oral administration. Since that time, tranexamic acid firmly occupies its niche in cosmetology. Particularly actively it is used in Japan and countries of South-East Asia.
At present, it is considered that tranexamic acid refers to means aimed at preventing the appearance of undesirable pigmentation.
The possibility of preventing UV
Correction of posttraumatic hyperpigmentation
Reparative (can be used after microdermabrasion, laser procedures, etc.) Feature whitening
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